

| Length | 355 miles |
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| Other names |
Louisville: Story Ave (WB)Mellwood Ave(EB) Brownsboro Rd Covington Area: Dixie HighwayPike St Main St Cincinnati Area: 2nd St (EB)3rd St (WB) Elm St (EB) Plum St (WB) Central Ave (WB) Central Parkway Reading Rd Lebanon Rd Columbus Cincinnati Rd Mason: Reading Rd
Lebanon: E Warren
Xenia: Cincinnati AveChurch St Main St Columbus St Cedarville: Xenia AveMain St Chillicothe St South Charleston: Xenia AveColumbus Rd London: High StElm St Lafayette St Plain City: Jefferson AveMain St Chillicothe St Delaware: William StLake St Ashley: Franklin St
Cardington: Main StGilead St Mount Gilead: Main StUnion St Lexington: Delaware StMain St Mansfield: Lexington AveMain St Diamond St (EB) Park Ave Ashland Rd West Salem: Buckeye St
Medina: Lafayette RdCourt St Cleveland Area Pearl RdW 25th St Detroit Ave Superior Ave |
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| Western terminus | Louisville, Jefferson County, KY, JCT US-31E/US-60 (Baxter Ave.) |
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| Eastern terminus | Cleveland, Cuyahoga County, OH, JCT US-6/US-20 (Public Square) |
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| Municipalities traversed (W to E) | Jefferson County (KY): LouisvilleIndian Hills Thornhill Harrods Creek Prospect Oldham County: River BluffGoshen Skylight Henry County: Sligo
Trimble County: Bedford
Carroll County: CarrolltonGhent Gallatin County: EthridgeWarsaw Boone County: BeaverlickUnion Florence Kenton County: ErlangerElsmere Edgewood Crestview Hills Lakeside Park Covington Hamilton County (OH): CincinnatiCoryville Avondale Evendale Sharonville Butler County: PisgahWarren County: MasonHageman Lebanon Waynesville Mount Holly Greene County: Spring ValleyXenia Wilberforce Cedarville Clark County: SelmaSouth Charleston Madison County: FlorenceLondon Lafayette Gillivan Plain City Union County: Plain CityArnold New California Delaware County: DelawareLeonardsburg Ashley Morrow County: CardingtonMount Gilead Williamsport Shauck Richland County: LexingtonMansfield Windsor Ashland County: AshlandWayne County: West Salem
Medina County: LodiLafayette Medina Brunswick Cuyahoga County: StrongvilleMiddleburg Heights Parma Cleveland |
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| Points of interest | Ohio River Paul Brown Stadium Cleveland Public Square |
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| Road intersections |
/||\ EXIT 7 \||/ || (end concurrency) || || /||\ EXIT 22 \||/ || || || || || || || || || || || || || || || || || || (0.2 mile duplex) || || || || || || || || || || || || || || || || (concurrency beyond OH state line) || || || || || || || || || || /||\
|| || (concurrency to OH state line) || || || /||\ EXIT 83 \||/ || || || /||\
|| || /||\
|| ||       Kentucky       Ohio || || || || || EXIT 2 || || /||\ \||/ || ||  ||\ \||/ || /||\ EXIT 46 \||/ || ||
(end concurrency) || (end concurrency) || || || /||\ \||/ || (0.6 mile concurrency) || || (end concurrency) || || || || || || || /||   ||/ || /||\ EXIT 79 \||/ || || || || /||\ \||/ ||
(end concurrency) || (1 mile concurrency) || /||\ (offramp, end concurrency) || (0.2 mile concurrency) || || || || ||
|| (end concurrency) || || ||
|| (end concurrency) || (Eastbound: 0.3 mile concurrency to JCT TRUCK OH-13, Westbound: 0.4 mile concurrency from JCT OH-430) || (Eastbound only: 0.3 mile concurrency) || (Eastbound OH-430: 0.4 mile concurrency from JCT TRUCK US-42/OH-13/430, Westbound: 0.6 mile concurrency to JCT OH-13 South) || (end concurrency) || || /||\ \||/ || || (to OH-60) ||  ||\ \||  (0.9 mile concurrency) || || || || || /||\
||  ||\ || (0.5 mile concurrency) ||
(end OH-3 concurrency) || || || /||  EXIT 161 ||  ||\ EXIT 234 \||  || || || || || /||\ EXIT 245  ||/ ||  ||\ EXIT 170A \||  || ||
|| (end US-42) |
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| Notes | The western portion of this road is split into two one-way streets in Louisville. AASHTO route logs are incorrect, having 42 ending at KY-61. As of 24 February 2008 there is no signage for 42 westbound beyond I-64 or eastbound before the intersection with Bickel Ave. I propose an "END US 42" sign be put in that goofy shaped traffic island! In Ohio, US-42 is sometimes referred to as State Route 42. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||